The general instability of eccentrically stiffened cylindrical shells under axial compression and lateral pressure

Instability of eccentrically stiffened cylindrical shells under axial compression and lateral pressur

Research impact evaluation, a wider context: Findings from a research impact pilot

In the face of increasing pressure to demonstrate the socio-economic impact of funded research, whether it is funded directly by research councils or indirectly by governmental research block grants, institutions have to tackle the complexity of understanding, tracking, collecting, and analysing the impact of all their research activities. This paper attempts to encapsulate the wider context of research impact by delineating a broad definition of what might be classified as impact. It also suggests a number of different dimensions that can help in the development of a systematic research impact assessment framework. The paper then proceeds to indicate how boundaries and criteria around the definition of impact and these dimensions can be used to refine the impact assessment framework in order to focus on the objectives of the assessor. A pilot project, run at Brunel University, was used to test the validity of the approach and possible consequences. A tool specifically developed for the pilot, the Brunel Research Impact Device for Evaluation (BRIDE), is used for the analysis of research impact collected during the pilot. The paper reports on the findings of the analysis produced by BRIDE and confirms how a number of areas might be greatly affected by the boundaries set on definition and dimensions of research impact. The pilot project shows that useful information on impacts can be generated and it also provides a way to identify areas of work from each unit of assessment for which it would be worth developing narrative case studies. The pilot project has illustrated that it is feasible to make progress in terms of assessing impact, but that there are many difficulties to be addressed before impact assessment can be incorporated into a system of assessing the impact from the university sector as a whole. The paper concludes with an institutional perspective of the value of the approach and highlights possible applications. It also confirms the intention to expand the pilot and introduce new lines of investigation

Cotton fireweed : potential poison : research roundup

Although long known as a potential toxic species because of its content, and although it is widely distribuited in all Australian States, cotton fireweed has not generally been consdidered toxic because it is unpalatable and not usually eaten by stock. In 1973 cattle deaths occured near Ravensthorpe which led to research into Senecio quadridentatus (cotton fireweed). The plant must be seen as a potential toxic species in situations where the lack of other feed forces cattle to eat the normally unpalatable cotton fireweed

Study of perturbed periodic systems of differential equations - The Stroboscopic method

Stroboscopic method for solving perturbed periodic systems of differential equation

Land Snails (Pleistocene-Recent) of the Loess Hills: A Preliminary Survey

The Loess Hills and Missouri Alluvial Plain landform regions of western Iowa were surveyed for molluscs in July and August, 1982. We focused on the modern fauna and that of the late Woodfordian (Wisconsinan) Peoria Loess, but a few localities with older and younger Pleistocene and Holocene faunas were also collected. Systematic bulk samples were taken at 95 localities: faunal lists for 75 are included herein. The modern land snail fauna comprises 40 species, most of which are small, drought-resistant cosmopolitan or Interior Province forms. One, or possibly two, Rocky Mountain forms survive as relicts. The modern fauna is depauperate in comparison to that of eastern Iowa. No definite endemic taxa were noted, but several succineid taxa require further study. The Peoria Loess fauna is more diverse and heterogeneous than the extant in its affinities. The total (47 species) includes major Interior Rocky Mountain, Northern, and Midwest Biome components as well as widespread taxa. The Interior element has many more deciduous forest taxa than currently survive. The poorly-known Holocene fauna (34 species) comprises mostly cosmopolitan and Interior taxa, with a few Rocky Mountain or extinct holdovers. In the Loess Hills region, diversity increases pronouncedly from north to south for both Peoria Loess and modern faunas. No clear trend is evident for the Missouri Alluvial Plain. Peoria Loess faunas are most diverse within a mile of the west bluff edge: diversity declines rapidly at more interior easterly sites

Estimates of the mean circulation in the deep (>2,000m) layer of the Eastern North Atlantic

A total of 131 current meter records of between 6 and 24 month duration are analysed to describe the deep flow field of the eastern North Atlantic from 19° to 54°N and from the Continental Slope to the Mid Atlantic Ridge. Mean flows are weak and may be statistically indeterminate in some records and locations, but appear to indicate cyclonic circulations around the Iberia and Porcupine abyssal plains with a generally southward flow along the Mid Atlantic ridge and a deep northward slope current (where measurements exist) along the eastern boundary. The deepest inflow to the north-eastern basin that has been identified to date takes place through the Discovery Gap of >4,700 m sill-depth at 37° 25′N 15° 45′W in the Azores-Portugal ridge. South of that ridge, observations are sparse and no systematic circulation is yet evident. These observations are discussed in relation to recent geostrophic estimates of the deep circulation

Short oestrous cycles in sheep during anoestrus involve defects in progesterone biosynthesis and luteal neovascularisation

Anoestrous ewes can be induced to ovulate by the socio-sexual, 'ram effect'. However, in some ewes the induced ovulation is followed by an abnormally short luteal phase causing a so called, "short cycle". The defect responsible for this luteal dysfunction has not been identified. In this experiment we investigated ovarian and uterine factors implicated in male-induced short cycles in anoestrus ewes using a combined endocrine and molecular strategy. Prior to ovulation, we were able to detect a moderate loss of thecal expression of steroid acute regulatory protein (STAR) in ewes that had not received progesterone priming (which prevents short cycles). At and following ovulation we were able to identify significant loss of expression of genes coding key proteins involved in the biosynthesis of progesterone (STAR, CYP11A1, HSD3B) as well as genes coding proteins critical for vascular development during early luteal development (VEGFA, VEGFR2) suggesting dysfunction in at least two pathways critical for normal luteal function. Furthermore, these changes were associated with a significant reduction of progesterone production and luteal weight. Additionally, we cast doubt on the proposed uterine-mediated effect of prostaglandin F2α as a cause of short cycles by demonstrating both the dysregulation of luteal expression of the PGF receptor, which mediates the luteal effects of PGF2α, and by finding no significant changes in the circulating concentrations of PGFM, the principal metabolite of PGF2α in ewes with short cycles. This study is the first of its kind to examine concurrently, the endocrine and molecular events in the follicular and early luteal stages of the short cycle

Gaps in the evidence on improving social care outcomes: findings from a meta-review of systematic reviews

Adult social care continues to be a central policy concern in the UK. The Adult Social Care Outcomes Framework (ASCOF) is a range of measures nationally available to drive forward improvement on outcomes and quality in local councils. While there is an emphasis on improving transparency, quality and outcomes, drawing on research evidence to achieve these aims is often difficult because the evidence is not easily identifiable, is disparate or of variable quality. We conducted a meta-review to analyse and summarise systematic review-level evidence on the impact of interventions on the four outcomes set out in the ASCOF: quality of life, delaying and reducing the need for services, satisfaction with services and safeguarding of vulnerable adults. This paper focuses on the availability of review-level evidence and the presence of significant gaps in this evidence base. A range of health and social care databases were searched, including MEDLINE, ASSIA and The Cochrane Library in January and February 2012. All systematic reviews evaluating the efficacy of social care interventions for improving ASCOF outcomes for older people, people with long-term conditions, mental health problems or physical and/or learning disabilities were eligible. Two reviewers independently screened systematic reviews for quality and relevance and extracted data; 43 systematic reviews were included, the majority of which examined the impact of interventions on quality of life (n = 34) and delaying and reducing the need for support (n = 25). Limited systematic review-level evidence was found regarding satisfaction with services and safeguarding. There were also significant gaps in relation to key social care interventions and population groups. Research priorities include addressing these gaps and the collation of data on interventions, outcomes and populations more closely related to social care. Overall, a more relevant, comprehensive and robust evidence base is required to support improvement of outcomes for recipients of adult social care

Tendency to contact general practice instead of self-care : a population vignette study

Background: Demand for general practice in the UK is higher than supply. Some patients seek appointments with GPs for minor illnesses rather than self-care. Aim: To identify the characteristics of people with a tendency to contact GPs rather than self-care. Design & setting: A national survey of the British adult population was undertaken in 2018, which included vignettes. Method: Two vignettes focused on illness in adults: half of responders completed a vignette about cough and sore throat for 3 days, and the other half completed a vignette about diarrhoea and vomiting for 2 days. Logistic regression was undertaken to identify characteristics associated with contacting GPs compared with dealing with the problem themselves, calling NHS 111, or contacting another service, including a pharmacist. Results: The response rate was 42%, with 2906 responders. Responders were twice as likely to select ‘contact GP’ for the diarrhoea and vomiting vignette than for the cough and sore throat vignette (44.7% versus 21.8%). Factors associated with tendency for GP contact included being aged >75 years (odds ratio [OR] 2.0, 95% confidence interval [CI] = 1.2 to 3.2); from black, Asian and minority ethnic (BAME) communities (OR 2.1, 95% CI = 1.5 to 3.0); feeling overwhelmed by unexpected health problems (OR 1.4, 95% CI = 0.99 to 2.1); lower health literacy (OR 1.2, 95% CI = 1.0 to 1.4); and believing that general practice is not overused (OR 1.3, 95% CI = 1.1 to 1.7). Conclusion: Type of symptom, personal characteristics, and population beliefs about general practice utilisation explain the tendency to contact GPs for minor illness amenable to self-care